FASCINATION ABOUT SIKIK

The functionality of SIK1 in tumorigenesis. SIK1 is usually a tumor suppressor gene, which performs a crucial regulatory position in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and impacts cancer mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 might also mark